“Look 25 Even At 40” Scientists Now Make Old Skin Cells Younger!

Good news! Scientists may have found the key to youthful skin! The Babraham Institute, a life sciences research institute in Cambridge, UK, recently conducted game-changing research. In this, old skin cells were reprogrammed to regain youthful function. They could make old skin cells younger by 30 years.

They stopped reprogramming halfway through the process. This novel technique avoids the difficulty of completely losing cell identification.

Using reprogramming to make cells younger while retaining their specialized functions, these researchers have made history.

Shinya Yamanaka was the first scientist to convert normal cells (with a specific purpose) into stem cells that can grow into any cell type. The whole stem cell reprogramming process takes around 50 days. This process involves four critical molecules known as Yamanaka factors.

They use the maturation phase transient reprogramming technique. This technique exposes cells to Yamanaka factors for 13 days. The cells momentarily lose their individuality.

Now it was crucial to see if the partially reprogrammed cells’ unique skin cell function returned. So, they were given time to develop under standard settings.

Current Research

make old skin cells younger

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Regenerative medicine is a multidisciplinary approach to treating chronic diseases, rapidly gaining popularity. 

The goal is to make old skin cells younger in the human body, whose capacity to function degrades. Making ‘induced’ stem cells is one of the essential tools in regenerative biology.

There is a push in regenerative biology to shift the sources of live cells for research objectives. Tissue and blood samples are being used to generate induced pluripotent stem cells. 

This can help develop novel therapies for conditions, such as heart disease, stroke, cancer, diabetes, and blindness.

The procedure has numerous phases, each of which erases a portion of the markers that differentiate cells. These stem cells can become any cell type in principle. But scientists are still unable to reliably duplicate the circumstance into the ones that allow stem cells to re-differentiate into all cell kinds.

After detecting collagen formation in the reprogrammed cells, genome analysis indicated that the cells had recovered markers indicative of skin cells (also known as fibroblasts).

Collagen in fibroblasts may help mend wounds and provide structure to tissues. This can’t only make old skin cells seem younger but also operate like youthful cells. 

Compared to control cells that were not part of the reprogramming process, the rejuvenated fibroblasts generate more collagen proteins.

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The researchers sought alterations in the signs of aging to suggest that the cells had been revived.

Researchers observed a variety of cellular age indicators. The first is the epigenetic clock, which uses chemical markers to signal age across the genome. The transcriptome, or all of the gene readouts produced by the cell, is the second. 

make old skin cells younger

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Based on these two metrics, reprogrammed cells had similar profiles to those of cells 30 years younger.

The partly regenerated cells were also evaluated by making an artificial incision in a layer of cells in a dish. They discovered that treated fibroblasts migrated faster into the gap than older cells.

The mechanism behind effective temporary reprogramming is yet unknown. Critical parts of the genome, important in determining cell identity may get spared from the reprogramming process.


Scientists being able to make old skin cells younger is a breakthrough. Furthermore, the road ahead may lead to alternative therapeutic possibilities. For instance, treatment of Alzheimer’s disease or cataract formation. The research, even though in the early stage, is up-and-coming.

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