After Italy announced its huge breakthrough for the coronavirus vaccine, Moderna (a US-based company) declared results of the Phase 1 human trial. It was satisfying and added an extra light of hope to the world in a fight against coronavirus.
There are chances by the year-end, or early-next-year to have a vaccine to prevent the Covid-19 from taking lives. Moderna coronavirus vaccine’s first phase human trial was done on 45 people.
These 45 healthy volunteers were of the age group between 18 to 55 years. They were divided into three groups of 15 people each. The good thing is all of them developed antibodies to fight against the virus on the 15th day after the single dose of mRNA-1273.
The first group was given the two doses of 25 micrograms of the vaccine. After two weeks of observation, the antibodies seen in the level of blood were equal to those seen in the sample of recovered COVID patients.
The second group was shot with a double dose of level 100µg on the 43rd day of the trial. One of the volunteers experienced redness around the injected area, which disappeared with time.
There was a significant increase in the antibodies in blood samples of the volunteers, and they were more than found in the recovered patients.
The third group received a shot of 250µg, but there isn’t much information about it available. Though researchers said, one of the candidates from the third group developed adverse systemic symptoms. Moderna said there was a relieving response of it, the symptoms seen were self-resolving.
30 out of 45 people had generated antibodies that bind the virus.
The final revelation of the Moderna COVID-19 Vaccine is, “It is safe and well-tolerated on the human beings. Didn’t show any Grade 4 or life-threatening effect after the trial.“
After the success of the phase 1 trial, the Moderna company’s president, Stephen Hoge said the vaccine does neutralize the virus, but 45 people are too little to consider the effect, soon we are planning to go on a phase 2 trial with around 600 people as a candidate.
In an interview with CBS, Hoge said: “Phase 2 trial will expand the safety and immunogenicity database.” He added, “This will confirm both that we’ve got the right idea of the dose where we believe we’re going to see protective immunity, as well as that the safety profile continues to hold up.”
After Phase 2, the Moderna is planning to move towards Phase 3 before the start of summer.
The chief medical officer at Moderna, Tal Zaks, said to STATS, 25µg of mRNA-1273 elicits the sufficient number of antibodies to fight against the virus, but we still need to have something like margin.
The new trial will have a dose of 50µg. The main purpose of establishing an ideal dose is to have its significant effect on senior citizens too. They are at a higher risk in this pandemic and need a notable boost in the immune system to fight against the SARS-Cov-2.
How Moderna Coronavirus Vaccine Works?
Normally the vaccines are developed based on the genetic structure of the virus. The genes of coronavirus changes as it comes in contact with the other person. The changes were small and can be tracked with closer observation.
Moderna pharma is known for its drugs and vaccines made based on ‘messenger RNA (mRNA) technology’ thought of using this method only to boost the immune system, which will fight against the virus and will fend them.
With this, the transmission level will also decrease, and soon the world will be free from coronavirus.
What is mRNA technology? It is a technology that relies on the body’s cells to produce viral proteins. After its injection, RNA slips into the human cells and let cells produce virus-like proteins (antibodies) that fight against the coronavirus.
Basically, it is a trigger to the human cells in producing protective antibodies.
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Stephen Hoge also addressed the distribution of vaccine to CBS.
He said, “Our goal is to have a vaccine available for broad distribution by year-end or early next year. If we and others build data that shows that the vaccine has potential for benefit, that it’s safe and has a potential for efficiency, then, of course, there are circumstances where the vaccine could be deployed to high-risk populations earlier under something called an Emergency Use Authorization. Really, that’s a decision that regulators, in particular the FDA, have to make.”
Let’s Keep Our Hopes High and Fingers-Crossed for the COVID-19 Vaccine:
Researchers and scientists all around the world are doing their best to find the vaccine for nCOV. They are on the run to find the cure, we can’t find the solution, but at least we can stay in our homes and safe until the vaccine is invented.
Let’s take an oath to stay safe and stay inside until the vaccine is out. Stay updated on coronavirus vaccine news with us at HealthClubFinder.